SSM Health Care of Wisconsin (SSMHC/WI) is a comprehensive not-for-profit Catholic health care system providing health care services to residents of and visitors to an 18-county area in south-central Wisconsin. SSMHC/WI, with headquarters in Madison, WI, is sponsored by the Franciscan Sisters of Mary and is owned and operated by SSM Health Care (SSMHC) based in St. Louis, Missouri.

SSMHC/WI provides health care services at two wholly-owned acute care hospitals, St. Mary's Hospital in Madison and St. Clare Hospital in Baraboo, as well as at two nursing homes — St. Mary's Care Center in Madison and St. Clare Meadows in Baraboo. St. Mary's Janesville Hospital in Janesville, WI, is the newest hospital and opened January 9, 2012.